Abstract
The localization of sialic acid in the trabecular meshworks of the normal human primary open-angle (POAG), congenital and juvenile glaucomatous eyes was investigated using both an electron microscope and lectins specifically binding with sialic acid. Sialic acid was always localized in fine fibrils lying underneath the canal wall and around collagen fibrils of the whole trabecular tissue. In both congenital and juvenile glaucoma, sialic acid was detected not only in the fine fibrils but also in the basement membrane-like materials in compact tissue present 3 μm underneath the canal wall. Sialated glycoprotein appears to play an important role in the pathogenesis of both diseases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
