Abstract
We searched for the cellular sites of prealbumin mRNA synthesis in fetal and adult mice by in situ hybridization technique. As early as at the 10th day of gestation (the earliest time point examined), prealbumin mRNA was detected in several different types of fetal cells, such as endo-dermal cells of the visceral yolk sac, tela choroidea, the predecessor of the choroid plexus, and hepatocytes. In the adult mice, prealbumin mRNA was localized in hepatocytes, choroid plexus epithelial cells, and inner and outer nuclear layers and ganglion cell layer of the retina. These observations suggest the possibility that prealbumin may have a function in neuronal systems different from its known functions concerning the plasma transport of both retinol and thyroxine.
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