Abstract
In this study the localizations of tachykinin neurokinin-1 (NK 1) and neurokinin-3 (NK 3) receptors in the guinea-pig brain are described. In agreement with studies in rat and human brain, the neurons that exhibited the most marked NK 1 receptor immunoreactivity were found in the dorsomedial caudate putamen. NK 1 receptors were also widely distributed in diencephalic structures and in the mid and hind brain. NK 3 receptors were distributed in both superficial and deep layers of the cortex and many appeared to be located on cells with astrocyte-like morphology in the glia limitans. In several regions including the thalamus, hypothalamus, amygdala, periaqueductal gray, substantia nigra and area postrema, both NK 1 and NK 3 immunoreactivity were found. The present study revealed that tachykinin receptors are widely distributed in the guinea-pig central nervous system.
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