Localization of lesions in dysgraphia: An investigation in the frame of the dual-route model of spelling

Abstract

Event Abstract Back to Event Localization of lesions in dysgraphia: An investigation in the frame of the dual-route model of spelling Claudio Luzzatti1*, Enrico Ripamonti2, Silvia Aggujaro3, Giuseppina Zonca4, Mirella Frustaci5 and Franco Molteni3 1 Università di Milano-Bicocca, Department of Psychology, Italy 2 IRCCS Fondazione don Carlo Gnocchi, Italy 3 Villa Beretta Rehabilitation Unit, Valduce Hospital, Costamasnaga, Italy 4 Istituti Clinici Scientifici Maugeri, IRCCS Montescano, Italy 5 ASST Rhodense, Passirana di Rho, Italy The neural bases of spelling (and its impairments) are still uncertain, and recent evidence from functional neuroimaging studies is not coherent with the results of modern aphasiology. In this study we aim at disentangling the neural bases of spelling using an anatomo-clinical correlative procedure in a cohort of 35 aphasic patients. Participants were classified as surface, phonological, mixed, undifferentiated dysgraphics using a multiple single-case diagnostic procedure. We employed the subtraction technique and voxel-based lesion-symptom mapping (VLSM) to highlight the anatomical correlates of functional damage along the lexical and sublexical routes. We found that surface dysgraphia is predominantly associated with left temporo-occipital lesions, along with lesions occurring in the left angular gyrus and supramarginal gyrus, and with partial involvement of the insula and external capsule. Phonological dysgraphia ensues from lesions in the left insular cortex, and the underlying external capsule. The left superior longitudinal fasciculus, corona radiata, and both the left putamen and pallidum seem to be involved in the sublexical network. Moreover, the middle frontal gyrus (Exner’s center) is implicated in the processing of both words and nonwords, and, as classically suggested, might be related with the grapho-motor component of writing. Data are consistent with dual-route models of spelling, and with a crucial role of white-matter pathways (in particular the external capsule) in spelling along both the lexical and the sublexical route. Figure 1 References DeMarco, A. T., Wilson, S. M., Rising, K., Rapcsak, S. Z., & Beeson, P. M. (2017). Neural substrates of sublexical processing for spelling. Brain and Language, 164, 118-128. Luzzatti, C., Laiacona, M., Allamano, N., De Tanti, A., & Inzaghi, M. G. (1998). Writing disorders in Italian aphasic patients. A multiple single-case study of dysgraphia in a language with shallow orthography. Brain, 121, 1721-1734. Roeltgen, D. P., & Heilman, K. M. (1984). Lexical agraphia. Brain, 107, 811-827. Keywords: Acquired dysgraphia, Dual-route model of spelling, Neuroimaging, Surface dysgraphia, Phonological dysgraphia Conference: Academy of Aphasia 55th Annual Meeting , Baltimore, United States, 5 Nov - 7 Nov, 2017. Presentation Type: poster presentation Topic: Consider for student award Citation: Luzzatti C, Ripamonti E, Aggujaro S, Zonca G, Frustaci M and Molteni F (2019). Localization of lesions in dysgraphia: An investigation in the frame of the dual-route model of spelling. Conference Abstract: Academy of Aphasia 55th Annual Meeting . doi: 10.3389/conf.fnhum.2017.223.00047 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Prof. Claudio Luzzatti, Università di Milano-Bicocca, Department of Psychology, Milano, Italy, claudio.luzzatti@unimib.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Claudio Luzzatti Enrico Ripamonti Silvia Aggujaro Giuseppina Zonca Mirella Frustaci Franco Molteni Google Claudio Luzzatti Enrico Ripamonti Silvia Aggujaro Giuseppina Zonca Mirella Frustaci Franco Molteni Google Scholar Claudio Luzzatti Enrico Ripamonti Silvia Aggujaro Giuseppina Zonca Mirella Frustaci Franco Molteni PubMed Claudio Luzzatti Enrico Ripamonti Silvia Aggujaro Giuseppina Zonca Mirella Frustaci Franco Molteni Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.