Abstract
D-serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl-D-aspartate (NMDA) receptors in mammalian brain. D-serine and serine racemase, which produces D-serine from L-serine, have long been presumed to be localized in astrocytes. However, we have reported that D-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of D-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for D-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that D-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors.
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