Localization of Cancer in Prostate Gland Using Innovative Ultrasound Method - Histoscanning

Abstract

The purpose of this study was to compare results of histoscanning with pathomorphological data, received during prostate biopsy. We examined 55 patients with suspicion of prostate cancer at the age of 55 - 84 years. All pts underwent DRE, a blood test for PSA, B-mode US, angiography, sonoelastography, histoscanning and target biopsy. 10 pts subsequently underwent radical prostatectomy. Mean PSA was 8.6 ng/ml. As a reference value for histoscanning we used a volume of pathological signal intensity 0.5 cc. Histoscanning results were compared with pathomorphological data, received after biopsy and radical prostatectomy, based on the presence and location of the tumor. Prostate cancer was diagnosed in 29 pts (53.7% of total pts). In 18% of cases we received true negative results, 25% - of false positive, and 4% - false negatives. The greatest interest to us was to identify tumor cells in central part of the prostate, so we decided to analyze statistics separately for peripheral and central part of prostate. For a central part, we received 88,8% Se, 40% Sp, 71,4% Ac, that exceeds similar parameters of B-mode and sonoelastography. Histoscanning with great accuracy determined the location of tumor areas, also located in the central part of the prostate.