Abstract
Nucleoside metabolites and synthetic nucleoside analogues used in the treatment of cancer and viral diseases cross lipid bilayers via specialized nucleoside transport proteins that are either equilibrative or concentrative. The concentrative nucleoside transporter family (CNT, SLC28) consists of three subtypes, CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3, respectively), that transport nucleosides together with an inwardly directed sodium gradient. Using the crystal structure of concentrative nucleoside transporter from Vibrio cholerae as a reference (Johnson et al, Nature 2012), models for human SLC28 and naturally occurring variants were generated.
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