Localization and function of NO-GC in the murine gastrointestinal and lower urinary tract

Barbara Lies,Andreas Friebe,Dieter Saur,Dieter Groneberg

doi:10.1186/2050-6511-14-s1-p37

Barbara Lies, Andreas Friebe + Show 2 more

Open Access

https://doi.org/10.1186/2050-6511-14-s1-p37

Copy DOI

Abstract

Background Nitric oxide (NO) is well known to stimulate NO-sensitive guanylyl cyclase (NO-GC) followed by production of cGMP and, eventually, to cause smooth muscle relaxation. Recent studies have shown that NO-mediated relaxation of gastrointestinal tissue is dependent on NO-GC in at least two cell types: smooth muscle cells (SMC) and interstitial cells of Cajal (ICC). In addition, the role of NO-GC in a novel interstitial cell type called fibroblast-like cells (FLC) in enteric neurotransmission is debated. In contrast, information about distribution and function of NO-GC in the lower urinary (LU) tract which comprises bladder and urethra is sparse. Here, we examined the function of NOGC in smooth muscle of the gastrointestinal (GI) and the LU tract.

Highlights

Nitric oxide (NO) is well known to stimulate NO-sensitive guanylyl cyclase (NO-GC) followed by production of cGMP and, eventually, to cause smooth muscle relaxation
Recent studies have shown that NO-mediated relaxation of gastrointestinal tissue is dependent on NO-GC in at least two cell types: smooth muscle cells (SMC) and interstitial cells of Cajal (ICC)
The role of NO-GC in a novel interstitial cell type called fibroblast-like cells (FLC) in enteric neurotransmission is debated

Summary

Introduction

Nitric oxide (NO) is well known to stimulate NO-sensitive guanylyl cyclase (NO-GC) followed by production of cGMP and, eventually, to cause smooth muscle relaxation. Localization and function of NO-GC in the murine gastrointestinal and lower urinary tract From 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications Erfurt, Germany. Background Nitric oxide (NO) is well known to stimulate NO-sensitive guanylyl cyclase (NO-GC) followed by production of cGMP and, eventually, to cause smooth muscle relaxation. Recent studies have shown that NO-mediated relaxation of gastrointestinal tissue is dependent on NO-GC in at least two cell types: smooth muscle cells (SMC) and interstitial cells of Cajal (ICC).

Results

Conclusion