Abstract
Introduction: The cancer stem cell of oral squamous cell carcinoma (OSCC) is reported to have relevance to growth of tumors and poor prognosis. Nanog protein is one of the transcriptional factors of embryonic stem cells. Recent data suggest that the expression of Nanog is up-regulated in tumor development. Although studies investigating the function of Nanog in cancers have shown that it plays several roles including cell proliferation, invasion and metastasis, the overall function of Nanog in cancer cells has remained elusive.
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