Abstract
Polycystic ovary syndrome (PCOS) is a cause of female infertility and its mechanism is still unclear. Tyrosine phosphorylated (TyrPho) proteins have been shown to be important for male infertility. However, the biological functions of TyrPho proteins involved in PCOS condition have never been reported. This study aimed to localize and investigate the TyrPho protein expression in PCOS rats. Twenty female Sprague‐Dawley rats were divided into control and PCOS (induced by letrozole, 1 mg/KgBW, for 21 consecutive days) groups. The estrus cycle of animals was confirmed by vaginal smear daily. At the end of experiment, ovary, oviduct, and uterus tissues of both groups were localized for TyrPho proteins by immunohistochemistry. In addition, the expression of TyrPho proteins in reproductive tissues were investigated and quantified. The results showed that TyrPho proteins were localized in the developing ovarian follicles and epithelial cells of oviduct and uterus. Moreover, TyrPho proteins were significantly overexpressed in ovary (68, 52, 42 and 28 kDas), oviduct (56 and 42 kDa), and uterus (170, 53 and 42 kDas) of PCOS group as compared to control. We concluded that female reproductive tracts have tyrosine phosphorylation essential for female fertility.Support or Funding InformationKhon Kaen University
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