Abstract

Purpose Purpose of this prospective, multi-institutional Phase I clinical study was to investigate whether MRI-guided transurethral ultrasound ablation (MR-TULSA), a novel minimally-invasive technology to treat organ-confined prostate cancer (PCa), is safe, feasible and effective. It employs directional plane-wave high-intensity ultrasound, which ablates prostate tissue using real-time thermometry with active temperature feedback control.

Highlights

  • Localised prostate cancer treated with MRIguided transurethral ultrasound ablation: phase I trial results

  • From International Cancer Imaging Society (ICIS) 14th Annual Teaching Course Heidelberg, Germany. 9-11 October 2014. Purpose of this prospective, multi-institutional Phase I clinical study was to investigate whether MRI-guided transurethral ultrasound ablation (MR-TULSA), a novel minimally-invasive technology to treat organ-confined prostate cancer (PCa), is safe, feasible and effective

  • Whole-gland prostate ablation was performed with MR-TULSA using the PAD-105 (Profound Medical Inc., Canada) and a 3T MRI (Siemens, Germany) in one single treatment session under general anaesthesia and 3D active MR-thermometry feedback control

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Summary

Open Access

Localised prostate cancer treated with MRIguided transurethral ultrasound ablation: phase I trial results. MB Wolf1*, M Roethke, S Pahernik, B Hadaschik, T Kuru, IV Popeneciu, G Hatiboglu, J Chin, M Billia, J Relle, J Hafron, K Nandalur, M Burtnyk, HP Schlemmer. From International Cancer Imaging Society (ICIS) 14th Annual Teaching Course Heidelberg, Germany. Purpose Purpose of this prospective, multi-institutional Phase I clinical study was to investigate whether MRI-guided transurethral ultrasound ablation (MR-TULSA), a novel minimally-invasive technology to treat organ-confined prostate cancer (PCa), is safe, feasible and effective. It employs directional plane-wave high-intensity ultrasound, which ablates prostate tissue using real-time thermometry with active temperature feedback control

Methods
Results
Conclusion

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