Abstract
GAMMA aminobutyric acid (GABA) has been demonstrated in invertebrate and vertebrate retinae1,2,3 and has been shown to have an inhibitory action on retinal neurones4. In vivo studies of 3H-GABA uptake by rabbit retina have shown a distribution of radioactivity in the inner plexiform layer, the amacrine cells of the inner nuclear layer, the ganglion cell and nerve fibre layers5. Further studies have shown that all layers of the rat retina except the outer zone of the rods will accumulate 3H-GABA in vitro6 in the presence of amino-oxyacetic acid (AOAA), an inhibitor of GABA metabolism7. Uptake was most pronounced in the ganglion cell and nerve fibre layer, inner nuclear and outer plexiform layers and at the outer limiting membrane. Furthermore, it was suggested that 3H-GABA might be largely taken up by Muller's fibres and their nuclei rather than by amacrine cells in the inner nuclear layer of the retina.
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