Abstract
The use of fluorescein or rhodamine conjugates of the serum globulin of patients with lymphadenoid goitre (Hashimoto's disease) permits the localisation in thyroid sections, including those from the same patient, of an auto-antigen wth the characteristics of thyroglobulin. This antigen was pressent in most of the follicles of all thyroids and in the hypertrophic follicular epithelial cells from toxic thyroids. The hypertrophied nuclei of such cells also contain areas of antigen possibly related to nucleoli. Intra-nuclear antigen is particularly prominent in the enlarged nuclei of lymphadenoid goitre. Some sera from cases of Hashimoto's disease (4 out of 25) contain an additional factor which localises to nuclei, and is possibly identical with the serum factor with a similar affinity for nuclei present in most cases of diseminate systemic lupus erythematosus. The localisation of these and other antigens is briefly discussed in relation to the pathogenesis of lymphadenoid goitre (Hashimoto's disease).
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