Abstract
WE have used in situ hybridisation to locate a major 5S RNA locus near the end of the long arm of chromosome 1 of man. This information represents a step towards the understanding of the synthesis, assembly and regulation of ribosomes. The 5S RNA molecule is associated with the larger ribosomal particle in both higher and lower organisms and is required for ribosome function. Ribosomal RNA—18S and 28S—is synthesised at the nucleolar organiser regions on the chromosomes of the D and G groups1. Genes coding for 5S RNA have been located in Drosophila2, Xenopus3 and several other organisms4, and our data now confirm preliminary reports5,6 that placed the 5S genes on chromosome 1 of man. We also suggest a mechanism for positioning the 5S genes near nucleoli at interphase.
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