Abstract
While chief resident physician in otolaryngology at the Graduate Hospital of the University of Pennsylvania, I became interested in the local effects of sulfathiazole on chronic mastoiditis. The effectiveness of sulfonamide drugs in the treatment of diseases which formerly had a high mortality rate challenges every physician today to discover more loci where chemotherapy may be applied. According to Kolmer, 1 ... the local or oral administration of sulfanilamide and its derivatives for the prevention of infection is worthy of serious attention and wider application. This is true not only in relation to superficial wounds and burns but with regard to the prevention of puerperal sepsis, gas gangrene, epidemics of sore throat, the extension of hemolytic streptococcic infection to the middle ear and mastoid cells, peritonitis after injury or the rupture of appendical abscesses, infection after accidental pricking of the fingers in the operating or necropsy rooms.... It is the
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