Abstract
We have developed an ointment preparation consisting of silver and zinc oxide nanoparticles, which form the basis of the nanocomposition. This drug can reduce the healing time of the wound surface due to the inclusion of nanodispersed particles in the composition. Application of nanoparticles allows to reduce inflammatory process, to carry out disinfecting treatment of a wound surface from pathogenic microorganisms, and accordingly to create optimum conditions for reparative process. Nanocomposite preparation has many advantages over existing analogues without irritating and allergic effects. Due to the high adsorption capacity, it allows to accelerate the healing process of the damaged surface of the skin. Initial studies were conducted on laboratory rats at the age of 6 months with a close mass that was up to 250 g in accordance with international requirements for the use of laboratory animals. As a result of the experiment, a new ointment preparation based on silver and zinc oxide nanoparticles, which are active components of the nanocomposition, was obtained. The use of these components allowed to accelerate the process of reparative restoration of the skin with full recovery of the studied animals. As shown by the experience, the recovery rate on average accelerated by seven days, compared with similar drugs available on the pharmaceutical market.
Highlights
Nanotechnology may prove to be actual in many fields of medical science, including traumatology, one of the major problems of which is the widespread increase in injuries of various etiology; an important place thereof takes skin breakdown, in particular, burn wounds
Recent studies have proved the effectiveness of nanoparticle-based drugs use, as the nanostructured particles ensure an equal increase in drug concentration in blood and tissues, even deeply penetrating body’s natural barriers such as skin and blood-brain barriers, producing high drug dose in lesions, providing an optimal therapeutic effect, and having a powerful antibacterial, bacteriostatic and antiviral effect
Various methods are used for silver nanoparticles synthesis, but the most commonly used method is based on the reduction of silver ions in solutions using various reducing agents
Summary
Recent studies have proved the effectiveness of nanoparticle-based drugs use, as the nanostructured particles ensure an equal increase in drug concentration in blood and tissues, even deeply penetrating body’s natural barriers such as skin and blood-brain barriers, producing high drug dose in lesions, providing an optimal therapeutic effect, and having a powerful antibacterial, bacteriostatic and antiviral effect. Various methods are used for silver nanoparticles synthesis, but the most commonly used method is based on the reduction of silver ions in solutions using various reducing agents. Such method is widespread due to its simplicity and availability [7,8,9,10]. There is fragmentary information about zinc nanoparticles producing anti-sclerotic effect, i.e. promoting the correction of microelement exchange at the tissue level, protecting the cells from the damaging action of enzymes, accelerating the healing of vast burn wounds by 15-20%, affected by the use of 10% zinc ointment, and about other quality indicators
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