Abstract
In December 2020, research surveillance detected the B.1.1.7 lineage of severe acute respiratory syndrome coronavirus 2 in São Paulo, Brazil. Rapid genomic sequencing and phylogenetic analysis revealed 2 distinct introductions of the lineage. One patient reported no international travel. There may be more infections with this lineage in Brazil than reported.
Highlights
In December 2020, research surveillance detected the B.1.1.7 lineage of severe acute respiratory syndrome coronavirus 2 in São Paulo, Brazil
Patient 1 was a woman 20– 30 years of age residing in São Paulo, Brazil, who reported no travel outside of Brazil
PCR testing (TaqPath COVID-19 PCR; ThermoFisher Scientific, https://www.thermofisher.com) performed as previously described (1) indicated that patient 1 was positive for the open reading frame 1ab and nucleoprotein (Ct 24.5) gene targets and patient 2 was positive for open reading frame 1ab (Ct 28.1) and nucleoprotein (Ct 27.29), but both were negative for the spike gene target
Summary
In December 2020, research surveillance detected the B.1.1.7 lineage of severe acute respiratory syndrome coronavirus 2 in São Paulo, Brazil. On December 30, 2020, we received saliva samples from 2 patients for genomic sequencing as part of research surveillance activities. We conducted whole-genome sequencing of SARS-CoV-2 by using the MinION platform (Oxford Nanopore Technologies, https://nanoporetech.com).
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