Local translation of mRNAs and its role in the development and plasticity of the mouse olfactory network

Abstract

Event Abstract Back to Event Local translation of mRNAs and its role in the development and plasticity of the mouse olfactory network Alain Trembleau1* 1 Université Pierre et Marie Curie Paris 6, 9 quai Saint Bernard, Equipe Avenir/INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102 - Neurobiologie des Processus Adaptatifs, France During the last decade, a growing body of evidence demonstrated that the regulated local translation of mRNAs in developing axons and mature dendrites could play critical roles in axon guidance and synaptic plasticity, respectively. However, little is known about molecular mechanisms at work in these regulations. Furthermore, several other possible functions of local translation have not been addressed yet. The project of my team is to investigate new functions of local translation in the development and plasticity of neurogenesis, making it amendable to in vivo manipulations. In the first part of my talk, I will present the approaches we develop in order to investigate the role of dendritic local translation in the processes of dendritogenesis, spinogenesis and synaptogenesis as new interneurons are functionally inserted into the adult olfactory bulb network. In the second part of my talk, I will present our recent data ocumenting a developmentally regulated local translation of Odorant Receptor-encoding mRNAs in olfactory sensory neuron axons, and I will discuss its possible role in the development and plasticity of the mouse olfactory map. Overall, our project addresses fundamental issues and molecular mechanisms involved not only in the normal development and plasticity of neural networks, but also in neurodevelopmental the mouse olfactory system, a model characterized by continuous pathologies like Fragile X mental retardation. Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Plenary lectures Citation: Trembleau A (2009). Local translation of mRNAs and its role in the development and plasticity of the mouse olfactory network. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.065 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Nov 2009; Published Online: 19 Nov 2009. * Correspondence: Alain Trembleau, Université Pierre et Marie Curie Paris 6, 9 quai Saint Bernard, Equipe Avenir/INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102 - Neurobiologie des Processus Adaptatifs, 75005 Paris, France, alain.trembleau@snv.jussieu.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alain Trembleau Google Alain Trembleau Google Scholar Alain Trembleau PubMed Alain Trembleau Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.