Abstract
The effect of a silastic implant made of polydimethyl siloxane tubing and containing 40 mg of norethindrone acetate has been studied in relation to its effect on the subcutaneous tissue of fifty women. Clinically, induration over the implant was detected in only one of them. The histopathology revealed connective tissue response to the silastic implant. The connective tissue showed progressive condensation and maturation of collagen and was associated with chronic inflammatory cell reaction,mainly mononuclear cells and foreign body giant cells. New capillary formation was also seen. However, no anaplastic changes of the fibroblasts were observed.
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