Local spindling in thalamus during cortical slow oscillation

Abstract

Event Abstract Back to Event Local spindling in thalamus during cortical slow oscillation P. Barthó1, A. Slézia1, F. Mátyás1, I. Ulbert2 and L. Acsády1* 1 Hung. Acad. Sci.,, Institute of Experimental Medicine, Hungary 2 Hung. Acad. Sci.,, Institute of Psychology, Hungary Despite being the main input and output of the neocortex, the relationship of thalamus during cortical oscillations is not yet fully explored. To investigate this, we performed simultaneous multiple single-unit recordings in rats under urethane anesthesia in the ventral posteromedial nucleus (VPM) and the S1 cortex with four-shank silicon probes. In the VPM two types of spikes were recorded. Wide spikes showed the characteristic burst pattern of relay cells, while narrow spikes fired longer and slower bursts and displayed asymmetric cross-correlograms with wide spikes. During thalamic spindle episodes the two types of spikes fired at different phases, wide spikes preceding narrow spikes by ~25 ms. Most of the VPM multiunit activity was organized into spindle episodes, which only occasionally coincided with cortical spindles. These thalamic spindles were usually restricted to one or two electrode shanks. Both types of units were phase locked to spindles. Considering that VPM contains only relay cells, we propose that narrow spikes belong to axon terminals originating in the nRt. To prove this, we performed simultaneous juxtacell recording of the nRt soma, and axon terminal in VPM. Our data show that network activity in VPM is organized into spatially restricted spindle episodes, indicating that cortical control over VPM is not very, and VMP-nRt interaction dominates instead. Keywords: Neurophysiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neurophysiology Citation: Barthó P, Slézia A, Mátyás F, Ulbert I and Acsády L (2011). Local spindling in thalamus during cortical slow oscillation. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00093 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. L. Acsády, Hung. Acad. Sci.,, Institute of Experimental Medicine, Budapest, Hungary, acsady@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers P. Barthó A. Slézia F. Mátyás I. Ulbert L. Acsády Google P. Barthó A. Slézia F. Mátyás I. Ulbert L. Acsády Google Scholar P. Barthó A. Slézia F. Mátyás I. Ulbert L. Acsády PubMed P. Barthó A. Slézia F. Mátyás I. Ulbert L. Acsády Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.