Abstract
To reproduce the local Schwartzmann phenomenon, heat-killed cells ofCitrobacter orEscherichiacoli were injected intradermally and intravenously into 11 germfree guinea pigs, two guinea pigs monoassociated withCitrobacter, and 25 control guinea pigs. All the germfree animals were refractory to the phenomenon, whereas 20 of the 25 control animals gave a positive reaction. A zone of infiltration at the site of intradermal injection was present in all the control guinea pigs but in none of the germfree animals. The possible primary and secondary mechanisms of suppression of the Schwartzmann phenomenon in the absence of the normal microflora are discussed.
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