LOCAL RECURRENCE OF PHYLLODES TUMORS OF THE BREAST : A META-ANALYSIS

Abstract

Background: Phyllodes tumors (PTs) are uncommon fibroepithelial breast tumors that are capable of a diverse range of biologic behaviors. In their least aggressive form, phyllodes tumors behave like benign fibroadenomas, although with a propensity to recur locally following excision without wide margins.Aim of Work: Our study focused on local recurrence and various risk factors of phyllodes tumors of the breast through a meta-analysis.Patient and Methods: This Review involved case-control studies, case report studies, and retrospective case follow-up evaluating local recurrence (LR) rates of unilateral or bilateral phyllodes tumors. phyllodes tumors of breast and assessing various risk factors for LR.Results: Forty-eight studies compared the LR risk between Benign / malignant. There was significant higher in Malignant VS Benign regarding rate of local recurrence p-value <0.001. Pooling of data from twenty-three showed significant difference in the LR risk between patients who underwent breast conserving surgery (BCS) and those who had a mastectomy p-value 0.001.Conclusion: The risk of LR was significantly increased from benign to borderline to malignant PTs, type of surgery, and surgical margin status may be risk factors for LR, while mitoses, tumor border, stromal cellularity, stromal atypia, stromal overgrowth, tumor necrosis had no difference regard increase risk for LR, Different management strategies could be considered for different PT grade.