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Abstract
To the Editor: Previously, we reported the use of whole-genome sequencing to investigate a putative methicillin-resistant Staphylococcus aureus (MRSA) outbreak in 2011 in the special care baby unit (SCBU) at the Cambridge University Hospitals National Health Service Foundation Trust (CUH) in the United Kingdom (1). The report identified 26 related cases of infection with or asymptomatic carriage of MRSA and showed that transmission occurred within the SCBU, between mothers on a postnatal ward, and in the community; the outbreak apparently resolved at the end of 2011. The outbreak strain, sequence type (ST) 2371, was of a novel multilocus ST related to the dominant hospital-associated lineage in the UK (ST22, EMRSA-15), but unlike most ST22 strains, this strain was Panton-Valentine leucocidin–positive (2). Since then, ST2371 has been identified as a prevalent community-associated MRSA clone in Southern India, and sporadic isolates have also been detected by whole-genome sequencing of MRSA in Denmark (3–5).
Highlights
To the Editor: Previously, we reported the use of whole-genome sequencing to investigate a putative methicillin-resistant Staphylococcus aureus (MRSA) outbreak in 2011 in the special care baby unit (SCBU) at the Cambridge University Hospitals National Health Service Foundation Trust (CUH) in the United Kingdom (1)
Phylogenetic comparison between these 10 isolates and the 45 isolates from the original outbreak demonstrated that these strains were highly related (Figure)
Case-patient C was born at the CUH and was not screened for MRSA, but both parents were case-patients in the SCBU outbreak (P20 and P26)
Summary
To the Editor: Previously, we reported the use of whole-genome sequencing to investigate a putative methicillin-resistant Staphylococcus aureus (MRSA) outbreak in 2011 in the special care baby unit (SCBU) at the Cambridge University Hospitals National Health Service Foundation Trust (CUH) in the United Kingdom (1). During April 2012–April 2013, we implemented genomic surveillance of MRSA isolated at the diagnostic microbiology laboratory at the CUH We undertook an epidemiologic investigation to determine whether links could be identified between these new cases and the original outbreak. The 10 isolates were cultured from 5 patients (case-patients A–E), all of whom had a direct or indirect link to the 2011 outbreak.
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