Local Ophthalmic Effects of Dipropylene Glycol Monomethyl Ether

Abstract

AbstractRabbit eye irritation tests showed undiluted dipropylene glycol mono-methyl ether (DPGME) to cause moderately severe conjunctoblepharitis which began to resolve by 24 hr with no residual injury by 7 days. Minor keratitis occurred between the first and third days. DPGME (40%) caused mild conjunctival effects of 24 hr duration, and DPGME (20%) was without effect. Instillation of 0.1 ml caused peak increased intraocular tension at 10 min, ranging from 2% [DPGME (10%)] to 27% [DPGME (50%)]. DlPGME (40%) caused mean peak increases in intraocular tension, at 10 min, ranging from <1% (0.01 ml) to 22% (0.1 ml). Tensions returned to control values between 1 and 48 hr. Corneal thickness, measured in vivo, increased following instillation of 0.1 ml DPGME; peak increases at 30 min-1 hr ranged from 5% [DPGME (10%)] to 20% [DPIGME (80%)]. Using DPGME (40%), peak increases in corneal thickness at 30–60 min ranged from 3% (0.01 ml) to 30% (0.10 ml). Corneal thickness returned to control values between 1 and 48 hr...