Abstract
The increase of drug-resistant pathogens is persistent in the control of pathogens. Several effective drugs have their roots in natural products, which have a traditional use in different diseases. To authenticate the efficacy of these traditional medicines, we selected the gastrointestinal tract infection as a target disease. Two plants Withania coagulans and Ehretia obtusifolia, were selected on the bases of their usage in folk medicine for the gastrointestinal tract complications. The bacteria selected were Escherichia coli, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, Vibrio cholera and Aeromonas spp. The crude extracts and fractions at three concentrations (15, 30, and 50 mg/ml) were tested for effectiveness against E. coli, S. dysenteriae, V. cholrea, S. typhi, P. aeruginosa and Aeromonas spp. The results show that the Ehretia obtusifolia has good activity against all test bacteria except S. dysenteriae while W. coagulans had activity against all the test bacteria.
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