Abstract
Over the past 2 decades, the survival of patients with metastatic colorectal cancer has improved considerably. With multidisciplinary treatment, a select group of stage IV patients can be treated with curative intent. The natural history and clinical course of stage IV rectal cancer varies considerably between individuals, and optimal management involves complex treatment decisions. The focus of this review is to explore the current issues and controversies surrounding the local management of the primary tumor in the setting of resectable as well as unresectable metastatic rectal cancer. The integration of systemic therapy and radiotherapy with surgical resection will be reviewed from various perspectives.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
