Abstract
Introduction: One of the most common primary malignant bone tumor is osteosarcoma that counts high percentages in the level of incidence the 5% of all tumor in children, and the 9% of all sarcomas. Osteosarcoma are malignant bone tumors developing from mesenchymal tumor cells that growth as disorganized immature bone or osteoid tissue. Patients affected by osteosarcoma show a peak incidence related to puberty (for young female 12±2 years and
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