Abstract
Ropivacaine is a new type of long-acting local anaesthetic of less systemic toxicity than bupivacaine. The objective of this double-blind study was to compare the efficacy and safety of ropivacaine 0.5% and mepivacaine 1% for infiltration anaesthesia in dermatologic surgery. Sixty out-patients aged 18–65 years, scheduled for excision of a benign naevus on the back, were randomly assigned to infiltration anaesthesia with either ropivacaine or mepivacaine. Both agents had a fast onset, and provided reliable anaesthesia and painfree surgery which could be carried out without the use of vasoconstrictive adjuncts or diathermy. Ropivacaine resulted in a longer duration of analgesia than mepivacaine, and both treatments were well tolerated.
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