Abstract
The preliminary experience at the Mallinckrodt Institute of Radiology with hyperthermia and irradiation is reported and current issues in clinical application of heat are reviewed. Twenty-nine lesions were treated with 400 rad fractions given every 72 hr (twice weekly) for a total dose of 2400 to 4000 rad followed by hyperthermia (1450-MHz or 915-MHz microwaves, 42.0 degrees -43 degrees, 90 min, every 72 h). Eight of 12 recurrent epidermoid carcinomas of the head and neck showed complete regression (67%) and one more than 50% response. Of 5 metastatic melanoma nodules treated with irradiation an hyperthermia, 4 (80%) showed complete regression of the tumors an 1 almost complete response. Of 9 recurrent adenocarcinoma of breast nodules in the chest wall treated with 3200 to 4000 rad 5 lesions exhibited complete regression and 2 others about 80%. Of 6 lesions treated with 1500 rad and hyperthermia (RTOG protocol), 2 metastatic melanomas showed complete regression (CR) and 3 tumors exhibited partial regression. Of the 35 sites treated, 4 (11%) developed blisters, 7 (20%) erythema only, 3 (8%) moist desquamation and 27 (77%) dry desquamation. Additional clinical trials are in progress to assess the potential value of hyperthermia alone or combined with irradiation in the treatment of selected cancer patients.
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