Local hemostatic biomaterial based on native collagen

Abstract

The article presents the results of obtaining a neutral biomaterial in the form of a sponge based on the aqueous mass of collagen isolated from the hide of cattle while maintaining the original fibrous structure. It has been established that at a concentration of water mass of collagen of 5-6%, a high porosity of the biomaterial is observed. With an increase in the porosity of the biomaterial, its sorption capacity increases. It is shown that the biomaterial “Hemogubka” with a porosity of 87% has a pronounced hemostatic effect in rabbits with increased bleeding, and also reduces the time of parenchymal bleeding of the liver, kidneys, and spleen in rabbits by 48-73%, respectively, and is superior in efficiency to the action of a hemostatic sponge and hemostatic gauze 1.2-1.5 times.