Abstract
The immune-response against infection withYersinia enterocoliticawas studied in a rat model which resembles yersiniosis in human. Lewis, Fischer and Brown Norway rats were inoculated withY. enterocoliticaand the cytokine mRNA expression in spleen and Peyer's patches was determined. In Brown Norway rats the infection was mild andYersinia enterocoliticawas fully cleared. In these rats the highest anti-inflammatory cytokine expression was found probably resulting in a protective host defence against the infection. In both the Lewis and Fischer ratsY. enterocoliticapersisted. The anti-inflammatory cytokine expression was less pronounced in these two rat strains. The authors conclude that progression of disease, persistence of infection and development of reactive arthritis, may be related to the local expression of specific cytokines.
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