Local endometrial injury in women with failed IVF undergoing a repeat cycle: A randomized controlled trial

Abstract

ObjectiveTo evaluate the effectiveness of local endometrial injury in women undergoing in vitro fertilization (IVF) with at least one previous unsuccessful attempt. Study designRandomized controlled trial. Recruited women were randomized into two groups. In group A (pipelle group), women underwent pipelle biopsy twice in the luteal phase in the cycle prior to IVF. In group B (control), women did not undergo any intervention prior to IVF. The primary outcome was clinical pregnancy rate. The secondary outcomes included live birth, miscarriage, multiple pregnancy and preterm delivery rates. ResultsOne hundred and eleven women were included in the study with 55 in the pipelle group and 56 in the control arm. The baseline clinical characteristics were similar in both groups. The clinical pregnancy rates were not significantly different between pipelle and control group (34.09% vs. 27.65%; Odds ratio, OR 1.35, 95% confidence interval, CI 0.55–3.30). The live birth (31.81% vs. 25.53%; OR 1.36, 95% CI 0.55–3.39), multiple pregnancy (33.33% vs. 61.54%; OR 0.31, 95% CI 0.07–1.47), miscarriage (6.66% vs. 7.69%; OR 0.86, 95% CI 0.05–15.23) and preterm delivery rates (35.71% vs. 66.66%; OR 0.28, 95% CI 0.05–1.4) were also not significantly different between the two groups. ConclusionCurrent study did not find any improvement in IVF success rates following endometrial injury in woman undergoing IVF after previous failed attempt.