Local drug-delivery balloon for proliferative occlusive in-stent restenosis after drug-eluting stent

Rigatelli Gianluca,Dell’Avvocata Fabio,Giordan Massimo,Cardaioli Paolo

doi:10.3724/sp.j.1263.2011.00065

Abstract

Drug-coated balloon has been developed as an alternative to drug-eluting stents for in-stent restenosis but the performance of drug infusion balloon in such setting has not been previously described. We present a case of particularly aggressive in-stent restenosis after drug eluting stent implantation treated with a new kind of drug infusion balloon developed in order to overcome the impossibility to inflate regular drug-coated balloon for several dilatation.

Highlights

Drug-coated balloon has been developed as an alternative to drug-eluting stents (DES)
We present a case of proliferative instent restenosis treated with a new type of drug eluting balloon
The presented case suggests that drug-infusion balloon can offer an effective therapeutic option in selected patients with very extensive in-stent restenosis after DES implantation

Summary

Introduction

Drug-coated balloon has been developed as an alternative to drug-eluting stents (DES). Results of several preclinical and clinical studies indicate that short-term exposure of injured arteries to paclitaxel eluted from regular Percutaneous Transluminal Angioplasty and PTCA balloons may be sufficient to reduce late lumen loss and restenosis rates during a critical period of time after angioplasty of diseased coronary and peripheral arteries.[1,2]. We present a case of proliferative instent restenosis treated with a new type of drug eluting balloon

Case report

Discussion