Abstract
The aim of this study was to explore the analgesic effect of local application of compound lidocaine/prilocaine cream on cancer wounds during wound care in order to reduce the amount of morphine intake or completely replace the systemic morphine administration and optimize the protocol for cancer wound pain management. All patients were enrolled with a visual analog scale (VAS) pain score ≥4. Before wound care, 60 patients were randomly divided into 2 groups of 30 each: morphine group (10 mg tablet); topical 5% compound lidocaine cream group (0.2 g/cm2). VAS scores, heart rate, and Kolcaba comfort level were recorded for the two groups 10 min before and 10, 15, 20, and 25 min after wound care and data were analyzed statistically. The means for the pain score and heart rate of the topical lidocaine/prilocaine cream group were lower than those of the morphine group (P<0.01) and the Kolcaba comfort level was higher (P<0.01). Local dermal application of the compound lidocaine cream can be used as an alternative to the systemic morphine administration in cancer wound care for its safety and effectiveness. In addition, it can improve the patients' comfort and quality of life.
Highlights
55–95% of patients with cancer wounds suffer with wound pain [1,2], which releases various stress hormones causing a severe stress response in the body that may interfere with normal physical and psychological status [3,4]
Considering the effective analgesic effect of compound lidocaine cream as an infiltrating anesthetic in cortical pain receptors and nerve endings, this study explored its application in the skin of incomplete cancer wounds as a method of pain intervention
Subjects From June 2015 to December 2017, 60 cases of patients with cancer wound pain treated in the wound outpatient department of the tumor center of a third-grade general hospital were selected as research subjects, including 24 cases of breast cancer, 2 cases of vulvar cancer, 8 cases of hypopharyngeal cancer, 16 cases of soft tissue sarcoma, 4 cases of laryngeal cancer, 4 cases of tongue cancer, and 2 cases of adenocarcinoma in 24 males and 36 females
Summary
55–95% of patients with cancer wounds suffer with wound pain [1,2], which releases various stress hormones causing a severe stress response in the body that may interfere with normal physical and psychological status [3,4]. Cancer wound pain is a complex pathophysiological process. Chronic wounds caused by long-term inflammatory reaction stimulate local skin afferent receptors and increase the sensitivity of peripheral nerves, leading to neuropathic pain. Cancer cells compress the wound bed tissue or erode the peripheral blood vessels and nerves, resulting in severe pain. Considering the effective analgesic effect of compound lidocaine cream as an infiltrating anesthetic in cortical pain receptors and nerve endings, this study explored its application in the skin of incomplete cancer wounds as a method of pain intervention
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
