Abstract
Recent advances in neuroimaging contribute a lot to the accurate diagnosis and evaluation of cerebrovascular diseases. To explore the relationship among blood perfusion, metabolism and brain structure integrity, 6 Chinese transient ischemic attack (TIA) patients with middle cerebral artery (MCA) stenosis were examined by xenon-enhanced computed tomography (Xe-CT), magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to compare cerebral blood flow (CBF) values, (choline + creatine)/ N-acetyl aspartate [(Cho + Cr)/NAA] values and fractional anisotropy (FA) values in the MCA territory. Our results showed that CBF values significantly decreased in the ipsilateral basal ganglion regions in all 5 cases with unilateral MCA stenosis, with a corresponding decrease of FA values in the same region. In conclusion, decreased blood perfusion may indicate nerve fibre damage in the dominating regions of stenosed arteries.
Highlights
Knowledge on recurrence, optimal evaluation and effecttive prevention strategy of transient ischemic attack (TIA) is still lacking
Average cerebral blood flow (CBF) values in bilateral regions of interest (ROIs) were different, with the maximum difference of 12.2 ml/(100 g·min), and the minimum of 1.5 ml/(100 g·min); CBF values significantly decreased in the ipsilateral basal ganglion regions of stenosed middle cerebral artery (MCA) in all 5 cases with unilateral MCA stenosis (P < 0.05). (Table 1) fractional anisotropy (FA) values in stenosed MCA territory were significantly lower than those in the contra-lateral counterparts in 5 subjects with unilateral MCA stenosis
xenon-enhanced computed tomography (Xe-CT) showed decreased CBF in the right basal ganglion, with CBF of 45.6 ± 17.0 ml/ (100 g·min) compared with 51.9 ± 19.9 ml/(100 g·min) in the right counterpart (p < 0.05) FA values in stenosed MCA territory were significantly lower than the counterpart. (p < 0.05) There was no significant difference between bilateral (Cho + Cr) /NAA values (p > 0.05) (Figure 1)
Summary
Optimal evaluation and effecttive prevention strategy of transient ischemic attack (TIA) is still lacking. An increasing body of evidence has revealed that TIA in Chinese population is more related to intracranial artery stenosis [1]. Recent advances in neuroimaging contribute a lot to the accurate diagnosis and evaluation of TIA and cerebrovascular stenosis. To address the relation between blood perfusion, structure integrity and metabolism in the brain, we enrolled Chinese TIA patients with middle cerebral artery (MCA) stenosis to compare cerebral blood flow (CBF), (choline + creatine)/N-acetyl aspartate [(Cho + Cr)/NAA] and fractional anisotropy (FA) values of MCA territory measure by xenon-enhanced computed tomography (Xe-CT) and magnetic resonance imaging (MRI)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
