Abstract

Antibiotics are valuable adjunctives for the management of bacterial infections. During endodontic treatment and when managing trauma to the teeth, antibiotics may be applied systemically or locally. Due to the potential risk of adverse effects following systemic application, and the ineffectiveness of systemic antibiotics in necrotic and pulpless teeth (due to the lack of blood supply which is required to distribute the antibiotic to the root canal system), the local application of antibiotics is a more effective mode for delivery during root canal treatment.

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