Abstract
ABSTRACTAgar cultures of C57BL bone marrow cells were used to determine colony stimulating factor (CSF) and serum CSF‐inhibitor levels in C57BL and BALB/c mice following irradiation. Whole‐body irradiation caused an acute, dose‐dependent, rise in serum CSF levels and fall in CSF‐inhibitor levels. The regeneration of granulocytic and macrophage progenitor cells (in vitro CFCs) in the femur after 250 rads whole‐body irradiation was preceded or paralleled by a fall in serum CSF‐inhibitors and a dramatic rise in the capacity of bone‐adherent cells in the marrow (‘stromal cells’) to produce material with colony‐stimulating activity. No comparable changes were observed in the activity of marrow haemopoietic cells during regeneration or in the lungs or spleen. A similar rise in the activity of bone‐adherent cells was observed in shielded femurs during regeneration of in vitro CFCs.Regeneration of granulocytic and macrophage progenitor cells following irradiation may be regulated by fluctuations in circulating CSF‐inhibitor levels and local production of CSF within the marrow cavity.
Published Version
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