Abstract
Abstract Purpose To search for the association between the –634 C/G polymorphism of the VEGF gene and vision threating proliferative diabetic retinopathy (PDR) and to determine whether vitreous levels of VEGF were affected by genetic factors. Methods In this cross sectional case‐control study 349 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled: 206 patients with vision threating PDR in whom vitrectomy was performed, and the control group of 143 subjects with type 2 diabetes of duration of more than 10 years who had no clinical signs of diabetic retinopathy. In 68 out of 206 patients with PDR (71 eyes) vitreous fluid samples (0.3 ml) were obtained by vitreoretinal surgery. Results The –634 C/G VEGF gene polymorphism was not associated with PDR. Moreover, significantly higher vitreous levels of VEGF were demonstrated in diabetics with the CC genotype compared to those with the other (CG + GG) genotypes. Conclusion Despite the effect of the –634 C/G VEGF gene polymorphism on vitreous levels of VEGF in PDR, it failed to contribute to the genetic susceptibility to PDR.
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