Abstract
1. 1. Fourteen patients with inoperable and far advanced cancers were subjected to local and general hypothermia. The lowest general temperature obtained was 77.6 degrees F. 2. 2. The periods of general hypothermia varied from thirty-six and one-half hours to 120 hours. Periods of local temperature reduction ranged from 236 hours to 792 hours. 3. 3. Twelve individuals were submitted to hibernation. One death occurred during hibernation, apparently because of cerebral edema superimposed on meningeal metastases. Eight deaths occurred three months to seven and one-half months following hibernation. Three patients are living three and one-half, four and one-half and eight months following hibernation. Two patients received only local cold; one lived one month; one lived nine months. 4. 4. All patients complaining of pain were relieved in whole or in part following hypothermia, either local or general.
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