Abstract
BackgroundMyelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS.Case presentationA 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding.ConclusionsWe demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time.
Highlights
Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow
We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time
Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow, which are characterized by ineffective hematopoiesis and morphological and functional abnormalities of hematopoietic cells [1]
Summary
Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow, which are characterized by ineffective hematopoiesis and morphological and functional abnormalities of hematopoietic cells [1]. There has only been one case report of a lung cancer patient with MDS who underwent surgery in the English literature [4]. We report a surgical case of a patient with lung cancer concomitant with MDS. Case presentation A 72-year-old man presented with cough He was referred to our hospital because of an abnormal shadow found on a chest x-ray. His medical history included chronic obstructive pulmonary disease and hyperlipidemia. A primary lung cancer (cT1bN0M0-stageIA2) was suspected; and the patient underwent bronchoscopy, which did not produce a definitive diagnosis. The patient is alive without any signs of lung cancer recurrence
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