Lobaplatin Inhibits the Proliferation of Hepatollular Carcinoma Through P53 Apoptosis Axis

Abstract

Cancer is a major killer nowadays, just as its name-a kind of hideous arthropods- which always goes through everywhere without restraints. little is known about how to repress its proliferation and destroy its defense. A lot of researchers focus on the antineoplastic agents which may suppress the proliferation and metastasis of Hepatocellular carcinoma(HCC) (1). HCC is the sixth most common tumor and the third leading cause of cancer deaths worldwide, particularly in Eastern Asia (2). Every year, billions of money is put into the researches about new drug account for HCC and the mechanism on apoptosis and cell cycle arrest of hepatoma cells (1, 3) Then the third generation platinum compounds emerge in time for the demand. Lobaplatin (D-19466;1,2- diammino-methyl-cyclobutaneplatium (II)-lactate) is one of platinum compounds and has presented encouraged anti-carcinoma activity in HCC without significant hepatotoxicity (4).