Abstract

Periodontitis can lead to the destruction of the alveolar bone. The loss of the alveolar bone can be treated using carbonated hydroxyapatite (CHA) as a bone graft material. However, CHA is an alloplastic graft whose primary function is to act as a scaffold, but it is unable to stimulate the process of bone regeneration. Carbonated hydroxyapatite is an avascular synthetic material, which will increase the risk of bacterial adhesion on site that can lead to unsuccessful periodontal therapy. The incorporation of propolis into CHA is expected to add antibacterial capability into CHA. Besides its antibacterial property, propolis also has a bone regenerating effect. Mixing CHA with propolis needs to consider the process of loading the active ingredients into the carrier. The release of propolis is expected to occur gradually over a lengthy period. The purpose of this study was to analyze the loading and releasing assay for propolis incorporated with CHA. A propolis solution of 5%, 7.5%, and 10% was each incorporated into 10 mg of CHA. The loading percentage and releasing assay of propolis were measured. The absorbance reading was done at 289 nm using a UV-vis. It was shown that a 10% propolis solution had the highest loading percentage (32.08%), while the 5% propolis solution had the smallest loading percentage (10.63%). The propolis releasing profiles in all concentration groups were similar. The difference in propolis concentration incorporated with CHA affected the loading percentage but did not affect the propolis releasing assay.

Highlights

  • Periodontitis is a chronic inflammation of the periodontal tissue that can lead to the destruction of the alveolar bone (Carranzza et al, 2012)

  • The calculation of loading percentage was done to determine the amount of absorbed propolis into the carbonated hydroxyapatite, which done by measuring the absorbance value before and after immersion

  • The highest loading percentage was found in group C (32.08%), and the lowest loading percentage was found in group A (10.63%)

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Summary

Introduction

Periodontitis is a chronic inflammation of the periodontal tissue that can lead to the destruction of the alveolar bone (Carranzza et al, 2012). The destruction of the alveolar bone can be treated using carbonated hydroxyapatite (CHA) as bone graft material. Carbonated hydroxyapatite is an alloplastic material that is biocompatible with the alveolar bone and possesses osteoconductive properties (Ana et al, 2010). It is a synthetic material that functions as a scaffold to maintain space but is unable to stimulate bone regeneration (Bashutski and Wang, 2009). Alloplastic materials are not vascularized because they are synthetic, which later leads to bacterial adhesion. Adding an antibacterial agent is suggested to prevent such adhesion (Filho et al, 2014)

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