LO-014 Mechanistic interrogation of STAT1 gain-of-function syndrome provides new insights into human lupus pathogenesis

Abstract

BackgroundHeterozygous STAT1 gain-of-function (GOF) mutations result in a predisposition to early-onset humoral autoimmunity, including lupus-like disease. Since multiple STAT1-dependent cytokines are implicated in lupus pathogenesis, we hypothesized that insights into...