Abstract
While long non-coding RNAs (lncRNAs) may play important roles in cellular function and biological process, we still know little about them. Growing evidences indicate that subcellular localization of lncRNAs may provide clues to their functionality. To facilitate researchers functionally characterize thousands of lncRNAs, we developed a database-driven application, lncSLdb, which stores and manages user-collected qualitative and quantitative subcellular localization information of lncRNAs from literature mining. The current release contains >11 000 transcripts from three species. Based on the accumulated region of lncRNAs, we classify transcripts into three basic localization types (nucleus, cytoplasm and nucleus/cytoplasm). In some conditions, the nucleus and cytoplasm types can be divided into three more accurate subtypes (chromosome, nucleoplasm and ribosome). Besides browsing and downloading data in lncSLdb, our system provides a set of comprehensive tools to search by gene symbols, genome coordinates or sequence similarity. We hope that lncSLdb will provide a convenient platform for researchers to investigate the functions and the molecular mechanisms of lncRNAs in the view of subcellular localization.
Highlights
Long non-coding RNAs are non-coding transcripts whose lengths are >200 nucleotides [1, 2]
According to the data we collect, we indicate that some Long non-coding RNAs (lncRNAs) are accumulated in chromosome or nucleoplasm in nucleus and some lncRNAs are accumulated in ribosome in cytoplasm
Increasing evidence has proven that lncRNAs play important roles in cell activities
Summary
Long non-coding RNAs (lncRNAs) are non-coding transcripts whose lengths are >200 nucleotides [1, 2]. Growing evidences suggest that lncRNAs have important function in various aspects of cellular function and biological process [8,9,10]. Unlike mRNAs, which are transported to cytoplasm and translated into proteins on ribosomes, lncRNAs have. Vol 2018, Article ID bay085 #LncRNA gene.
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