Abstract
Long non-coding RNA small nucleolar RNA host gene 8 (SNHG8) has been found correlated with cancer progression. This work was aimed to investigate the functions of SNHG8 in ovarian cancer (OC). Expression level of SNHG8 in OC tissues and cells was analyzed using real time-quantitative polymerase chain reaction (RT-qPCR) method. The biological roles of SNHG8 in OC were analyzed through proliferation assay, wound healing assay, and transwell invasion assay. Furthermore, interactions of SNHG8 or S100 calcium binding protein A11 (S100A11) and microRNA-1270 (miR-1270) were explored. Moreover, the effects of SNHG8, miR-1270, and S100A11 on the overall survival of OC patients were investigated. SNHG8 has increased expression in OC tissues and cells compared with normal counterparts, and correlated with poorer overall survival of OC patients. OC cell proliferation, migration, and invasion abilities were enhanced by SNHG8 overexpression but inhibited by its knockdown. In addition, we showed that SNHG8 regulates OC progression through targeting the miR-1270 and S100A11. Our work indicated that SNHG8 regulates OC progression through miR-1270/S100A11 axis, which may provide novel therapeutic targets for OC.
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