Abstract
Prostate cancer remains one of the most prevalent cancers and the main causes of cancer‐related deaths in males. Various articles introduced that long noncoding RNAs (lncRNAs) are found in vital functions in the development and progression of cancers. Although SNHG3 (small nucleolar RNA host gene 3) has been investigated in many cancers, now researches on the role and mechanism of SNHG3 in prostate cancer are lacked. In this work, SNHG3 exerted high expression in prostate cancer cell lines. Suppression of SNHG3 inhibited cell proliferation, migration, EMT (epithelial‐mesenchymal transition) process and promoted cell apoptosis. Additionally, it was found that SNHG3 could bind with miR‐577. Subsequently, SMURF1 (Smad ubiquitination regulatory factor 1) was identified as a downstream target of miR‐577 and had a negative correlation with miR‐577. SNHG3 was found to positively regulate SMURF1 expression. Furthermore, rescue assays demonstrated that co‐transfection of pcDNA3.1/SMURF1 reversed the effects of SNHG3 knockdown in cell proliferation, migration, EMT process and cell apoptosis. SNHG3 also promoted tumorigenesis in vivo. All the results above explained that SNHG3 accelerated prostate cancer progression by sponging miR‐577 to up‐regulate SMURF1 expression, suggesting that SNHG3 may act as a biomarker for prostate cancer patients.
Highlights
Long noncoding RNAs are longer than 200nt and lack the potential of coding proteins
All the results above explained that small nucleolar RNA host gene 3 (SNHG3) accelerated prostate cancer progression by sponging miR-577 to up-regulate Smad ubiquitination regulatory factor 1 (SMURF1) expression, suggesting that SNHG3 may act as a biomarker for prostate cancer patients
Previous studies have demonstrated the role of Long noncoding RNAs (lncRNAs) SNHG3 in cancers
Summary
Long noncoding RNAs (lncRNAs) are longer than 200nt and lack the potential of coding proteins. Plenty of lncRNAs have been scrutinized and the roles of them in cancer have been studied.[1,2] For example, lncRNA GHET1 can play the function of activating the cell growth of gastric carcinoma via regulating messenger RNA (mRNA). Many lncRNAs are dysregulated in prostate cancer.[11] For instance, lncRNA625 is up-regulated in prostate cancer cells and sponges miR-432 to activate the Wnt/β-catenin signaling for modulating the progression of prostate cancer.[12] lncRNA small nucleolar RNA host gene 3 (SNHG3) has been identified as oncogene in many cancers, such as hepatocellular carcinoma, colorectal cancer, glioma, ovarian cancer, and osteosarcoma.[13,14,15,16,17] the role of SNHG3 is still not clear in prostate cancer. The regulatory effects of SNHG3 on SMURF1 were probed, which might shed a new insight into the molecular mechanism of prostate development
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