Abstract
Anaplastic glioma is Grade III and the median overall survival is about 37.6 months. However, there are still other factors that affect the prognosis for anaplastic glioma patients due to variable overall survival. So we screened four-lncRNA signature (AGAP2-AS1, TPT1-AS1, LINC01198 and MIR155HG) from the lncRNA expression profile from the GSE16011, CGGA and REMBRANDT datasets. The patients in low risk group had longer overall survival than high risk group (median OS 2208.25 vs. 591.30 days; P < 0.0001). Moreover, patients in the low risk group showed similar overall survival to Grade II patients (P = 0.1669), while the high risk group showed significant different to Grade IV (P = 0.0005) with similar trend. So based on the four-lncRNA, the anaplastic gliomas could be divided into grade II-like and grade IV-like groups. On the multivariate analysis, it showed the signature was an independent prognostic factor (P = 0.000). The expression of four lncRNAs in different grades showed that AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while TPT1-AS1 was decreased. Knockdown of AGAP2-AS1 can inhibit the cell proliferation, migration and invasion, while increase the apoptosis cell rates in vitro. In conclusion, our results showed that the four-lncRNA signature has prognostic value for anaplastic glioma. Moreover, clinicians should conduct corresponding therapies to achieve best treatment with less side effects for two groups patients.
Highlights
Glioma is the most common brain tumor and it has high morality and recurrence rate [1]
We assessed the prognostic value of this signature compared with Grade II and IV gliomas
TPT1-AS1 was higher expressed in low risk group, so we considered it as a protective lncRNA
Summary
Glioma is the most common brain tumor and it has high morality and recurrence rate [1]. AGs comprise 6–10% of all primary brain tumors [3] and the median overall survival (OS) is about 37.6 months [4]. Many studies have revealed a wide range of functional activities of lncRNAs [7, 8], including chromatin remodeling, transcriptional control and posttranscriptional processing, et al The dysregulation of lncRNAs might contribute towards glioma pathogenesis, such as cellular proliferation and apoptosis [9,10,11,12]. Aberrant expressions of lncRNAs may have prognostic value for AG patients and can be exploited as potential therapeutic targets [13, 14]
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