Abstract
Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic condition. Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo. Moreover, OIP5-AS1 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis which is IDH2 or hypoxia inducible factor-1α (HIF-1α) dependent. In cervical cancer cells, OIP5-AS1 promotes IDH2 expression by inhibiting miR-124-5p, and IDH2 promotes the Warburg effect of cervical under hypoxic condition through regulating HIF-1α expression. In conclusion, hypoxia induced OIP5-AS1 promotes the Warburg effect through miR-124-5p/IDH2/HIF-1α pathway in cervical cancer.
Highlights
Many life activities, such as growth, reproduction, maintaining their structure, and responding to the external environment, require energy consumption, which are mainly supplied by adenosine triphosphate (ATP), and sugar metabolism is the most important ATP generation pathway
We found that OIP5-AS1 was a hypoxia-responsive long-chain non-coding RNA (lncRNA) and was essential for hypoxia-enhanced glycolysis which is IDH2 or hypoxia inducible factor-1α (HIF-1α) dependent
To analyze the correlation between OIP5-AS1 expression and clinical features in cervical cancer patients, and found that (Table 3) OIP5-AS1 expression in cervical cancer tissues was significantly related to tumor size, differentiation, lymph node metastasis and FIGO stages of cervical cancer
Summary
Many life activities, such as growth, reproduction, maintaining their structure, and responding to the external environment, require energy consumption, which are mainly supplied by adenosine triphosphate (ATP), and sugar metabolism is the most important ATP generation pathway. It has been recognized for a long time that cancer cells have a unique way of glucose metabolism, Warburg effect, characterized by even in an oxygen-enriched environment, cancer cells are mainly powered by glycolysis, and oxidative phosphorylation is reduced (Warburg, 1956). The results in the present study suggest that hypoxia induced OIP5-AS1 promotes the Warburg effect through miR-124-5p/IDH2/HIF-1α pathway in cervical cancer
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