Abstract
LncRNAs have become a hot topic in various cancer-related researches. Radio-resistance is a great threat for cancer therapy. However, how lncRNAs affect the radio-resistance in cervical cancer is masked. As for our paper, it was discovered that NEAT1 was highly expressed in cervical cancer tissues and non-sensitive tissues as well as radio-resistant cell lines. And the overexpression of NEAT1 accelerated proliferation, while the knockdown of NEAT1 had the opposite result. The effect of NEAT1 on cell proliferation was dependent on the dose of ionizing radiation. And the silence of NEAT1 also caused cell cycle arrest in G0/G1 phase, and triggered more apoptosis, indicating the oncogenic role of NEAT1 in cervical cancer. Next, mechanistic assays affirmed that NEAT1 could function as a ceRNA to regulate cyclin D1 through sponging miR-193b-3p in cervical cancer. Rescue assays were employed to validate that miR-193b-3p and cyclin D1 could inhibit NEAT1-mediated suppressive effect on proliferation, and its stimulative effect on cell cycle arrest and apoptosis. In general, this article disclosed that NEAT1 could facilitate the radio-resistance of cervical cancer via competitively binding miR-193b-3p to up-regulate the expression of cyclin D1.
Highlights
As one of the most familiar malignant cancers for the female, cervical cancer (CC) takes a great proportion of cancer-associated mortalities around the whole world [1, 2]
This article disclosed that NEAT1 could facilitate the radio-resistance of cervical cancer via competitively binding miR-193b-3p to up-regulate the expression of cyclin D1
NEAT1 is elevated in cervical cancer tissues, non-sensitive tissues and radio-resistant cells
Summary
As one of the most familiar malignant cancers for the female, cervical cancer (CC) takes a great proportion of cancer-associated mortalities around the whole world [1, 2]. More than 529800 patients with cervical cancer are diagnosed every year and about 275100 of them face death [2]. Even though the patients suffering from cervical cancer can receive relevant treatments such as surgical operations, radiotherapy and chemotherapy, the positive survival fraction for them is still awful [1, 3]. There are many papers discussing the functions of lncRNAs in cell cycle and differentiation [11] as well as in cell apoptosis [12, 13]. Thereby, it can be inferred that lncRNAs is a critical factor in dealing with the diseases associated with cancers. We discussed the role of lncRNA NEAT1 in the radioresistance of cervical cancer. It was discovered that NEAT1 was highly expressed in cancer tissues, nonsensitive tissues and radio-resistant cancer cells. NEAT1 enhanced the radio-resistance of cervical cancer through promoting cell proliferation, causing cell cycle arrest and triggering cell apoptosis
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