Abstract
PurposeMIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis.ResultsMIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes.ConclusionMIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis.
Highlights
Osteoarthritis (OA) is a common clinical degenerative joint disease that is characterized by subchondral bone thickening, degradation of articular cartilage, and the formation of osteophytes [1]
We showed that MIR4435-2HG was downregulated in osteoarthritis and regulated chondrocyte cell proliferation and apoptosis
Downregulation of MIR4435-2HG in join fluid effectively distinguished osteoarthritis patients from the control group MIR4435-2HG in join fluid was measured by qPCR
Summary
Osteoarthritis (OA) is a common clinical degenerative joint disease that is characterized by subchondral bone thickening, degradation of articular cartilage, and the formation of osteophytes [1]. Osteoarthritis has become a major problem of public health worldwide, and more than half of people aged older than 65 years are suffering from this disease [2]. With the increase in people’s life expectancy, the incidence of osteoarthritis is predicted to be further increased in the near future [4]. Several risk factors have been characterized for osteoarthritis, the pathogenesis of this disease is still unclear and definitive cure is not available [5]. Long non-coding RNAs (lncRNAs) have no protein-coding capacity, there are key players in the development of human diseases [6, 7].
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